The 11-year-old girl was given a 75 percent chance of survival if she underwent chemotherapy.
But her family chose instead to stop the treatment and visit the Hippocrates Health Institute in West Palm Beach, a center the state says is run by a man who is not a physician.
In March of 2014, Makayla was diagnosed with Acute Lymphoblastic Leukemia.
Canadian media says she underwent 11 weeks of chemotherapy at McMaster Children's Hospital in Ontario.
After weeks of treatment, she wrote a letter to her parents, saying "this chemo that I'm on is killing my body and I cannot take it anymore."
Her uncle says, against her doctor's will, her parent took her out of treatment.
While her mother says the family did spend time at the Hippocrates Health Institute, it was not to treat Makayla's cancer.
But Her uncle says, seeking indigenous medicine practiced at Hippocrates was in fact the family's goal, and it was their right to choose.
Canadian media reports the Brant Family and Children's Services investigated the case and decided not to force treatment on Makayla.
Makayla died last month from a stroke. Her parents released a statement saying "Chemotherapy did irreversible damage to her heart and major organs. This was the cause of the stroke."
But an oncologist says Makayla suffered a relapse which led to her death.
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